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arundhati bag, lalit mohan jeena and niladri bag
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john brick
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luiz eduardo imbelloni, md, phd, doctor of anesthesiology faculty of medicine of botucatu, são paulo, brazil, e-mail: dr.imbelloni@terra.com.br
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mingjun he, jianjun mu*, fuqiang liu, keyu ren, yang wang and tongshuai guo
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renaud de beaurepaire
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somchai amornyotin
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Nov 23, 2018
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Ribosomal P proteins are small molecules (10-11 kDa) that form the ribosomal stalk structure which plays a key role in the elongation step of protein translation [1]. Ribosomal P proteins have an isoelectric point in a very acidic range (pI 3-4), and are phosphorylated. For these reasons, they are also called acidic ribosomal P proteins. In addition to ribosome-bound P proteins, they are also found in a free-state in cytoplasm and an exchange occurs between the nucleus and cytoplasmic sites...
Topic: Allergenic Ribosomal P Proteins
Acinetobacter species are important nosocomial pathogens because they can develop resistance to antibiotics and survive for a long time in the hospital environment. This study aimed to investigate the changes in antibiotic resistance profiles of Acinetobacter spp. strains isolated from blood speciemens of hospitalized patients in our hospital.
Topic: Identification of Bacterial Pathogens in Blood
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Background and objective: This work collects and analyses information about the evolution of medical practice during the last centuries. The main aim is to summarise new insights on “omics sciences” and their impact in medicine. Methods: Use of appropriate keywords, use of different engines of research information and the subsequent bibliometric analysis of the information.
Topics: Genomic, Transcriptomic, proteomic
Clostridium difficile is a Gram-positive spore-forming anaerobe that can be found in the stomach and the intestines of healthy people. There are two forms of C. difficile bacteria – an active form that cannot survive in the environment for long periods of time and the dominant form, a spore, which can survive for a long period of time. Spores are very difficult to remove from surfaces and therefore can contaminate the environment by living on them for weeks to months. Spores cause infection...
Topic: The First Evidence of Epidemic Strain Clostridium Difficile (027/NAP1/BI) in Eastern Croatia
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Nov 23, 2018
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Talin is a large cytoskeletal adaptor protein that is an important component of focal adhesion complexes of adherent cells. It was originally identified as a component of focal adhesions and ruffling membranes of fibroblasts. It was the first cytoplasmic protein partner of integrins to be identified. Many studies proved that talin connects the intracellular actin cytoskeleton with the extracellular environment through interactions with integral membrane proteins in the dynamic focal adhesions....
Topic: Talins and Cancer
A total of 174 E. coli isolates collected from healthy poultry, bovine and ovine recovered between December 2009 and June 2013 in different geographic location in Tunisia, were assessed and examinated for resistance to antimicrobial agents. Avian isolates showed the highest rates of antibiotic resistance: tetracycline (74.7 %), trimethoprim/sulfamethoxazole and amoxicillin with the same rate of resistance (57 %). Prevalences of resistance to the same four antimicrobials in bovine isolates were...
Topic: Antimicrobial Resistance in Escherichia coli Isolates from Healthy Poultry
The present study is aimed to determine the preliminary phytochemical screening and antibacterial activity of acetone extract of the edible plants, Solanum nigrum (L.), Murraya koenigii (L.), Sesbania  grandiflora (L.) against urinary tract infection causing bacteria in children. These edible plant extracts were checked for their antibacterial activity by the agar disc diffusion method. The preliminary phytochemical screening of this extract revealed the presence of alkaloids, proteins, amino...
Topics: Phytochemical constituents, Antibacterial activity, Edible plants, Urinary tract infection
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Dengue virus is one of most rapidly growing arthropod born viral disease in the world which has serious health and economic implications. Dengue infection can lead to life threating condition with no specific drug or vaccine currently available for its treatment or prevention. The scenario of dengue infections in developing and under developed countries is very grim with increase in the number of endemics and poor health care infrastructure. The situation in central India needs more attention...
Topics: Dengue, Epidemics
IL28B’s SNPs are considered the most important host factors predicting the success of Peg-INF alpha/ribavirin based regimens against Hepatitis C virus (HCV) infection. However, the associations of HBV mediated etiologies have not been well documented. This study investigated the relationship between the three most clinically relevant IL28B SNPs (rs8099917, rs12980275, and rs12979860) with the risk of HBV/HCV infection and HCC development within Vietnamese HBV carriers. By using kinetics and...
Topics: HBV, HCV, HCC
Background & Aim: Despite the drug resistance M.bovis and Mycobacterium tuberculosis (MTB) are still regarded as two of the global health problems in the world. In the present study, a comparison was made between protein profiles of M.bovis and MTB in order to achieve effective biomarkers for diagnosis of TB. The clinical samples, sputum and gastric lavage (and the other samples) were processed by N-acetyl-Lcysteine-sodium hydroxide methods and consequently were cultured on...
Topic: Membrane and Secretory Protein Extraction of Mycobacterium
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Nov 23, 2018
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Talins were the firstly identifi ed cytoplasmic protein partners of integrins. Vertebrates have two talin genes, TLN1 and TLN2, which encode Talin-1 and Talin-2, respectively. Talin-1 is essential for cell adhesion and motility and is the primary talin component of focal adhesions. Many studies have demonstrated, involvement of talins in different mechanisms inside many body cells, induction of some diseases. Moreover, recent and ongoing research indicates the diagnostic and prognostic roles of...
Topics: Talins, Talin1, Talin2, Integrins, Biomarker
Background: The search of rapid methods for the detection of Escherichia coli in coastal marine waters is a topic of scientific interest to evaluate potential risks to human health related to their low bacteriological quality.  The context and purpose of the study: A miniaturized assay for the analytical determination of β−glucuronidase activity in seawater as a selective marker of Escherichia coli was developed by using the chromogenic Indoxyl-β-D-glucuronide (IBDG) substrate. This...
Topics: Fecal pollution, Seawater
Streptococcus constellatus can sometimes cause serious invasive infections, as infections of the liver and lung, brain abscesses, bacteraemia, endocarditis and intra-abdominal infections. The study aimed to identify S.constellatus and to assess their susceptibility to several antibiotics. Methods: In a 59-year-old patient hospitalized in intensive unit care for an epidural abscess, pus was collected and bacterial were grown, then bacterial identification was performed by routine laboratory...
Topic: Antibiotic Susceptibility of the First Streptococcus Constellatus
Heavy metals pollution in aquatic ecosystem is global issue due to persistence and continuous accumulation of these pollutants in aquatic environment. This results in excess release of heavy metals such as cadmium, copper, lead, nickel, zinc etc. The contamination by heavy metals in plants and water is one of the major issues to be faced throughout the world and requires attention because heavy metals above their normal ranges are extremely threatened to both plant and animal life. The Common...
Topics: cadmium, Biochemical parameters
Primary spindle cell rhabdomyosarcoma of the prostate is an uncommon variant of embryonal rhabdomyosarcoma seen in pediatric age group mostly during infancy and childhood. Rhabdomyosarcoma (RMS) arising from prostate predominantly presents obstructive urinary symptoms. To date, only one case of the spindle cell variant of embryonal rhabdomyosarcoma of the prostate have been described in literature. The delay in diagnosis and a more aggressive behavior of this malignancy contributed to an...
Topics: Rhabdomyosarcoma, Prostate, Primary, Immunohistochemistry
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The rectum is considered the straight part of the bowel although it’s not straight with at least three folds. Sometimes defi ned as the last 12 cm of the large bowel other consider it as the last 15 cm. Surgeons mark it starting at the anorectal ring, anatomist use the dentate line, more consensus and agreements is needed for the rectum as a structure. Also there is a lot of difference between the upper and lower part of the rectum, anatomically and embryologically. Differences between both...
Topic: Is it Time for the Introduction of Colostomy Free Survival in Rectal Cancer Patients
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Oral cavity squamous cell cancer (OSCC) and Oropharynx squamous cell carcinoma (OPSCC) are the most frequent forms of Head and Neck Cancers (HNCs) [1]. About 300,000 new cases of oral cancers are being counted yearly worldwide, having registered an increase of incidence of 225% in U.S.A. in the last 20 years, with about 50% of related deaths [2,3]. The relevant advances in treatments of OSCC during the last decades, allowed updated surgery techniques, robotic surgery, intensive induction...
Topic: Diagnosing HPV-Related Oropharyngeal Cancers:
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Decavanadate compounds were described to be involved in a variety of biological activities and responses such as anti-virus, anti-bacterial and anticancer. While the mechanisms of action of the antiviral and anti-bacterial activities are better understood, the same does not go for the anti-tumour activity. Nevertheless, the inhibition of tumour proliferation seems to impact certain enzymes such as alkaline phosphatase, ecto-nucleotidases or P-type ATPases. In the present report, several studies...
Topics: Decavanadate, Anticancer, Polyoxometa- lates (Poms)
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Introduction: Granular cell tumours (GCT), also known as Abrikossoff’s tumours, are rare, and occur in the breast in approximately 5-6% of the cases these tumours are usually benign with only 1% of malignancy. Case Presentation: A 57-year-old Caucasian woman presented with a palpable mass that was growing progressively in the axillary tail of the left breast, with no other associated symptoms, and no family history of breast cancer. 
Topics: Granular Cell Tumour, Abrikossoff’s Tu- mour, Breast Cancer, Case Report
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Nov 23, 2018
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Background: Disease Management (DM) is an approach to health care that coordinates resources across the entire health care delivery system and throughout the course of a disease. Objectives: The purpose of the present study was to evaluate the DM implementation in a country like Greece, with distinct geographical characteristics and non-symmetrical distribution of health care services. 
Topics: Disease management, Greek health care system, Information technology, Cost control, Out- comes,...
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Cutaneous angiosarcoma is a rare and aggressive malignant tumor of vascular origin. Multimodality treatment including surgery, radiotherapy and chemotherapy should be used according to age and local spread. Prognosis is poor with a 5-year survival of 10-15%. We report the case of an angiosarcoma of the scalp and face treated with sequential contact radiotherapy and chemotherapy. After local response, the patient progressed in non-irradiated zone then had liver metastasis.
Topics: Angiosarcoma, Scalp, Face, Treatment, Radiotherapy, Surgery, Chemotherapy
In the past few years, immunotherapy, particularly immune checkpoint inhibitors, have redefi ned standard of care cancer treatment for numerous malignancies. However, despite the wealth of promising data and great enthusiasm, the vast majority of cancer patients still fail to respond to these therapies as single agents. In tumors which are thought of as immunogenic (e.g. renal cell, urothelial, non-small cell lung cancer (NSCLC)) the response rate to single agent immune checkpoint inhibition...
Topic: MEK Inhibitors in Combination with Immune Checkpoint Inhibition: Should we be Chasing Colorectal...
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Nov 23, 2018
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Cancer is a leading cause of death in men worldwide and the major cause of cancer related death is drug resistance [1,2]. In past few years, scientists have established tumor heterogeneity as a phenomenon of critical importance in the natural history of individual neoplasms and drug resistance [3-5]. The concept of tumor heterogeneity has a major impact on therapeutic approaches [6-9]. Drug resistance creates difficulty in cancer treatment and is directly linked to the tumor progression and...
Topic: Role of tumor heterogeneity in drug resistance
Penile carcinoma is a rare malignant disease with a significantly higher incidence in some areas of underdeveloped countries [1]. Inguinal nodal involvement is found in 20% to 40% of cases at diagnosis and nodal metastasis is an important predictive factor for survival [2,3]. Metastatic penile carcinoma has an extremely poor prognosis, since reported results of systemic therapy have been disappointing, even when improvement is achieved [4-12].
Topic: Video Endoscopic Inguinal Lymphadenectomy: Re fi ning surgical technique after ten years experience
Background: The aim of this study was to evaluate ovarian damage following laparoscopic endometrioma cystectomy using ultrasound and pathologic samples.  Materials and Methods: This is a prospective cohort study in General Women Hospital affiliated to Tehran University of Medical Sciences. 40 patients with endometrioma, total of 44 cysts including bilateral cysts, underwent laparoscopic cystectomy with stripping technique. Amount of excised parenchyma, number of lost oocytes and cyst wall...
Topics: Endometrioma, Cystectomy, Laparosco- py, Ultra sonogram, Histopathology, Ovarian reserve
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Introduction: Paget’s disease of the vulva (PDV) is a very rare malignancy originating in vulvar apocrinegland-bearing skin cells. Based on multi centric nature of Paget’s disease, it’s a chronic and relapsing course. The aim of this report is to introduce a case of multi centric Paget’s disease and review of literature.
Topics: Paget’s disease, Multi centric disease, Carcinoma, Review of literature
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Nov 23, 2018
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Stem cells isolated from menstrual fluid have mesenchymal stem cell like properties and have multi lineage differentiation capacity. Menstrual fluid has ease of access in collection and repeated sampling is possible in a noninvasive manner. Also, rapid culture of these is possible in numbers that are sufficient for therapeutic use. They are, hence, looked upon as a novel innovation and are finding a place in the current medicine practice
Topics: Menstrual stem cells, stem cells
Objective: The primary goal of this study was to assess the G-CSF effects on IVF outcomes in women with normal endometrial thickness.  Patients and Methods: This was a randomized controlled study performed at Assisted Reproductive Techniques Center of Ain Shams University Maternity Hospital, over a 2-year period, between Jan 2014 and Jan 2016, and included 60 infertile women with normal endometrial thickness. Women were scheduled for IVF and randomized into two groups. Exclusion criteria were...
Topics: Granulocyte colony stimulating factor, Unexplained Infertility, In vitro- fertilizatio
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Background: Antepartum fetal death (AFD) contributes significantly to stillbirths (SB) in low- and middle-income countries (LMIC). Modifying locally-prevalent demographic risk factors could lessen the burden of SB in the region.  Objective: This study seeks to identify the prevalence and modifiable socio-demographic risks for antepartum fetal death (AFD) in a Nigerian setting with the aim of recommending appropriate interventions to reduce the burden. 
Topics: Antepartum, fetal death, socio-demo- graphic factors, stillbirths, Nigeria
Ectopic pregnancy remains an important cause of morbidity and mortality in the fi rst trimester of pregnancy, and has become a major public health challenge among women in the reproductive age group in this environment. A review of 139 consecutive cases of tubal ectopic gestations managed over a fi ve year period at the Ekiti State University Teaching Hospital, Ado – Ekiti, Nigeria was conducted. Ectopic pregnancies accounted for 1.8% of all deliveries. Most of the women were married (68.3%),...
Topics: Abdominal paracentesis, Tubal Pregnancy, Management, Resource-poor, Nigeria
Objectives: To evaluate awareness and acceptability of HPV vaccine amongst medical students in a tertiary teaching hospital.  Materials and methods: This was a cross sectional descriptive study carried out in a tertiary hospital in South India in January 2015. A self-administered questionnaire in English was given to 310 undergraduate medical students after obtaining consent. Parameters studied included awareness and acceptability of HPV vaccine. Data was analysed using SPSS 16 software. 
Topics: HPV vaccine, Awareness, Acceptability
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Intrauterine devices (IUD) are a highly effective and safe form of contraception. However, many individuals, particularly nulligravidas, elect against IUD use due to fear of pain associated with insertion. Misoprostol has been proposed as an agent to ease IUD insertion and decrease associated pain. However, its efficacy in the literature is inconclusive and its use varies widely between healthcare providers. We present a review on the efficacy of vaginal misoprostol in facilitating IUD...
Topics: Intrauterine device, IUD, Contraception, Insertion, Misoprostol
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Placenta percreta in early pregnancy is rare and only few cases are documented. We report a case of placenta percreta at 10 weeks gestation. Sonography revealed absence of line of demarcation between trophoblast and myometrium extending to the urinary bladder region. Termination of pregnancy by hysterotomy was done. The diagnosis and treatment of placenta accreta in early pregnancy must be taken seriously which might protect patients from considerable bleeding and further morbidity
Topics: Placenta percreta, Placenta accrete, Cesar- ean section scar, Hysterotomy
Objective: The aim of this study is to identify the role of sFlt-1/PIGF ratio as a prognostic marker for cases of preeclampsia.  Patients and methods: The current study is a case control study that was conducted over 90 cases of primigravida patients, 24-34 weeks of gestation, randomly selected patients from outpatient clinic and ER of Ain Shams Maternity Hospital, they were classified into two groups, first group is preeclampsia group which was 45 preeclamptic pregnancies (preeclampsia...
Topics: Soluble FMS-like tyrosine kinase (SFLT-1), Placental growth factor (PLGF), Preeclampsia
Objective: The study aims to test the effect of tranexamic acid (TA) on uterine vasculature and blood loss after vaginal delivery.  Materials and methods: A randomized, double-blind, placebo-controlled trial, conducted in Assiut Woman’s Health Hospital, Egypt between the 1st of October 2015 and the 31st of March 2016 included pregnant women (37-42 weeks) with a single living cephalic fetus. The eligible women were randomized to receive TA or placebo after vaginal delivery. Doppler indices...
Topics: Postpartum hemorrhage, Tranexamic acid, uterine blood fl ow, Doppler
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Pregnancy, another state or gravidity, is the state of a woman who carries a new being. The fertilization and ends with childbirth. The fertilized egg develops and goes through several different stages of development: embryo and fetus. Diagnosing pregnancy is based on safe and unsafe signs, and most reliable evidence that ultrasound. Pregnancy lasts nine months and the vast majority of women is well tolerated. Unfortunately, there are women who do not stand up well due to certain health...
Topics: Woman, Pregnancy, Medicine, Health, Law
Aim: of the study was to investigate the difference of distribution and expression of the lysyl oxidase enzymes (LOX), the pro-collagen C proteinase (PCP) and the myofibroblasts in the vaginal tissue of postmenopausal women, with and without prolapse. 
Topics: LOX, PCP, Myo fi broblasts, Actin, Extracel- lular matrix, Pelvic organ prolapse, Menopause
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Uterine sarcomas are neoplastic malignancies that typically arise in tissues of a mesenchymal origin in uterine body. The identifi cation of novel molecular mechanisms leading to sarcoma formation, and the establishment of new therapies and biomarkers has been hampered by several critical factors. Uterine leiomyosarcoma (U-LMS), which is the most common sarcoma, is rarely observed in clinical settings, with fewer than 15,000 new cases being diagnosed each year in the United States. Another...
Topics: Leiomyosarcoma, LMP2, Tumour protein 53 (TP53), Retinoblastoma (RB)
Objective: Urinary incontinence (UI) is a common condition and a global health concern, the burden of this condition is greatest in developing countries of Asia, South America and Africa. The current study aims to assess and compare the psychological symptoms and quality of life (Qol) of women with UI in Assiut (Egypt) and Sana’a (Yemen). 
Topics: Incontinence, Quality of life, Urinary, lPsychological
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In our study, the aims are typing and investigating of Human Papillomavirus (HPV) in cervical swab samples by multiplex real time polymerase chain reaction (PCR). Besides PCR results and cytological evaluation of the samples were compared. 
Topics: HPV, PCR, Cervical cytology
Various hemostatic agents are currently available for routine laparoscopic procedures, avoiding thermal lesions due to energy devices and the complexity of intracorporeal sutures, however, evidence of complications in immunocompromised patients is still lacking. We present the case of a severely immunocompromised gynecological patient who underwent a routine laparoscopic cystectomy, where a local hemostatic agent was employed; further complications arose, a second diagnostic laparoscopy...
Topics: Hemostatic agent, Pelvic abscess, Lapa- roscopy, Immunocompromised patient, Cystectomy
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Nov 23, 2018
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Background: Preterm birth is a major health concern. It is the leading cause of perinatal mortality and morbidity. Besides varied etiology, it may be due to alteration in basic biochemical function of the body at cellular level stating emphasis to trace elements of which magnesium, being one of them. Pregnancy is marked by a state of hypomagnesaemia and varied hypomagnesaemia observed in preterm labor cases. 
Topics: Preterm labor, Maternal magnesium, Cord milking
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Cervical cancer is the leading cause of morbidity and mortality among gynecological cancers worldwide. Cervical cancer is the main cancer found in developing countries. There are risk factors for cervical cancer worldwide, mainly persistent infection of high risk HPV, especially genotypes 16 and 18 viruses. Cervical cancer prevented when precursor lesions detected and treated before they develop cancer. Cervical cancer is preventable, and effective screening programs reduce morbidity and...
Topics: Cancer mortality, Cytology, Colposcopy, Cervical cancer, Visual inspection, HPV testing, Vac-...
Objective: The present study examines the hypothesis that the clinical and ultrasonography data reported at baseline visit can predict the responsiveness of ibuprofen in controlling heavy menstrual bleeding with Cu-IUDs at 3 months follow-up visit. 
Topics: Intrauterine device, Heavy menstrual bleeding, Ibuprofen, Doppler
Background: Chronic Obstructive Pulmonary Disease (COPD) is characterized by a complex range of pathological changes including both pulmonary and systemic effects. Several mechanisms contribute to  the variable intermediate and clinically relevant disease phenotypes, such as chronic bronchitis and emphysema, and systemic disease. The molecular mechanisms associated to the pathogenesis of COPD are not yet clearly understood. 
Topics: Oxidative Stress, Antioxidants, In fl amma- tion, Chronic Bronchitis, Emphysema
Objective: To  evaluate  the  utility  of  inspiratory  capacity  (IC)  measured  by  simple  spirometry  as  an indirect measure of air trapping. Method: Functional  residual  capacity  (FRC)  and  IC  were  determined,  respectively,  by  a  body plethysmography and by spirometry. Air trapping was defined by a FRC higher than 120%. Spearman’s rho between IC and FRC is determined and the receiver operating characteristic (ROC curve) is calculated as predictive of air...
Topics: Chronic obstructive pulmonary disease, Air trapping, Inspiratory capacity, Spirometry
Objective : Although, the use of humidification during non-invasive ventilation (NIV) is an important factor in decreasing nasal airway resistance and assuring patient’s comfort and adherence; many in-vitro studies recommend switching off the humidifier while delivering aerosol to NIV patients.
Topics: Nebulizer, Non-invasive ventilation, Humidi- fi cation, Urinary salbutamol, Filter, CPAP
A  autoimmune  Pulmonary  Alveolar  Proteinosis  (PAP)  patient  with  persistent  disease  underwent  3 Whole Lung Lavages (WLLs), 10 plasmapheresis sessions and further 3 WLL, from October 2004 to May 2007. Nevertheless HRTC and pulmonary function test (PFT) showed a persistent residual disease of mild degree. At the beginning of 2010, the patient was admitted to inhaled rGM-CSF (Sargramostim) therapy as compassionate treatment. GM-CSF was administered by Akita 2 nebulizer...
Topics: Inhaled therapy, Pulmonary alveolar pro- teinosis, GM-CSF, Whole lung lavage
Aim: To examine  whether  caloric  intake  during  the first  week of age influences the risk  of Bronchopulmonary Dysplasia (BPD) in extremely preterm infants. Methods : In this retrospective cohort study, all infants born with gestational age < 29 weeks over 30 months period were eligible for the study. Infants with major congenital anomalies and those who died before 36 weeks postmenstrual age were excluded. We compared the nutritional characteristics between infants who developed...
Topics: Preterm infant, Bronchopulmonary dyspla- sia, Calorie intake, Protein
Introduction: Mucoproduction plays an important role in the processes of tumor progression, invasion and metastasis. In non-small cell lung cancer (NSCLC), mucins hypersecretion has been associated with alterations in the epidermal growth factor receptor (EGFR) expression. However, the relation of mucins with EGFR in these tumors is not completely clarified. 
Topics: Non-small cell lung cancer, Clinic-patho- logical features, Mucin production, Epidermal growth...
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Introduction: Cystic lung diseases are a heterogeneous group of pathologies which differential diagnosis can be complicated[1]. We are going to comment some aspects that we should know about cystic lung diseases to facilitate a better understanding and clinical management of these entities.
Topic: What do we have to know about Cystic Lung Diseases
Background  and  objective: Hypoxia/reoxygenation  (H/R)  is  a  key  factor  in  the  pathogenesis of the most lung diseases  where exсessive  ROS  production and  prooxidant/antioxidant  imbalance greatly contribute to disease progression. We have used severe hypoxia in sessions of repeated H/R of different duration as  a model of lung  pathologic  states  to  investigate  mitochondrial  oxidative  stress  intensity, protein   expression/activity of antioxidant...
Topics: Hypoxia/reoxygenation, Protein expres- sion, MNSOD, Glutathione peroxidase, P53, NF-KB, Lung...
Introduction: The  inhalation  route  remains  the  mainstay  of  therapy  for asthma  and  chronic obstructive  pulmonary  disease  (COPD). This confers  a  number  of  advantages  such  as  delivery  of medication  directly  to  the site of  action  resulting  in  faster onset. It also allows  smaller  doses  to  be  administered  and therefore significantly reduces systemic side effects compared with oral therapy. The drug treatment regime for the majority...
Topic: Effectiveness of Asthma Inhaler Pharmacotherapy must take into consideration both
Abstract: Vascular Ehlers-Danlos Syndrome (EDS) presents with fragility of blood vessels, with high incidence of fatal hemorrhages in middle-age adults. We present a 38-year old female with vascular EDS presented to  the  emergency  unit  with  spontaneous  hemomediastinum  and  hemothorax. A selective arteriography showed  a  bronchial  artery  aneurysm  that  could  be  embolized. Coagulated  hemothorax  was cleared up using intrapleural instillation of urokinase. Acute...
Topics: Ehlers-Danlos syndrome, Bronchial aneurysm, Haemomediastinum, Haemoperitoneum
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Nov 23, 2018
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Interstitial lung disease (ILD) is a term that describes a group of more than 200 lung disorders that show varying degrees of inflammation and fibrosis of the pulmonary interstitium. The etiology  and  pathophysiology of many of these disorders still remains poorly understood and is the topic of ongoing research and  debate. The  diagnostic  approach  to ILD can  be  complex and  often  requires  a  multidisciplinary  team  approach  with involvement  of  a  pulmonologist, ...
Topic: Usefulness of Transbronchial
Background: Detection  of  dermatophytes  by  microbiological  method  is  sometimes  problematic and  some  atypical  microscopic  or  macroscopic  morphology  are  non-detectable.  Due  to  morphological similarity  and  existing  intermediate  forms  and  variants,  unequivocally  separating  these  dermatophytes is  not  always  straightforward,  and  sampling  appropriate  isolates  for  research  is  often  troublesome.The  aim  of  this ...
Topics: Dermatophytes, Genotyping, Clinical Samples
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Background: Thymic carcinomas (TC) are rare tumors with challenging diagnosis and management. We aimed to describe the clinical and microscopic characteristics of TC through a literature review. Results: 82 articles and abstracts were retained about 2913 TC. Our study contained 1760 men and 1153 women with a mean age of 55.32 years. The delay of diagnosis was specified in 10 cases and varied between 8 months and 2 years. Symptoms consisted mainly in chest pain and dyspnea. The Computed...
Topics: Thymic carcinoma, Diagnosis, Pathology, Treatment
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Background: A subpopulation of Pseudomonas aeruginosa (PsA) exists in cysticfibrosis (CF) patients that  is  hypersusceptible  to  ticarcillin,  a  carboxypenicillin,  in  vitro (Tichs strain)  defined  as  a minimum inhibitory concentration (MIC) ≤4μg/ml. Methods: In a retrospective cohort study, isolates of PsA from CF (23),  non-cystic fibrosis bronchiectasis (NCFB) (17) and control (18) patients were analysed. MICs for each isolate were determined using agar dilution against...
Topics: Pseudomonas aeruginosa, Cystic fi brosis, Non-cystic fi brosis bronchiectasis, Tic hs strain,...
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Cystic fibrosis (CF) is the most common and fatal autosomal recessive genetic disease in euro-descendents. It affects about 85,000  people  worldwide  [1].  It  is  characterized  by  multiple and  systemic  clinical  manifestations  that  primarily  affect exocrine  sweat  glands,  lungs  and  pancreas  while  presenting great  variability  in  its  severity  [2].  It  is  caused  by  mutations in  the cystic fibrosis  transmembrane  conductance  regulator ...
Topic: The Importance of Genetic Study in Cystic Fibrosis
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The authors describe a case of syringomyelia associated with Chiari malformation Type I in a patient who was referred to a respiratory service with features of obstructive sleep apnoea. The patient exhibited clinical features of scoliosis, hoarseness, sensory and motor neurological deficit and vertical upbeat jerk nystagmus. The authors review the various factors in the pathogenesis of this unusual constellation of symptoms, signs and radiological findings
Topics: Syringomyelia, Nystagmus, Vocal cord palsy, Sleep aponea, Hiccups
Prostate cancer develops slowly and is frequently diagnosed in elderly men, and its treatments are  associated with adverse effects on the urinary and sexual function of patients [1]. Radical prostatectomy (RP) may reduce the disease-specifi c mortality of patients with prostate cancer, although this approach has been shown to have long-term negative complications with no improvement in overall patient survival [2]. Chen et al. [3], recommended that longitudinal measurement of patients’...
Topic: Outcome Changes after Diverse Radical Prostatectomy among Prostate Cancer Patients
Background: Nursing bridging education (NBE) refers to educational programs that support learners to move from one level of educational preparation or practice to another. In the context of this study, NBE refers specifi cally to an educational focus that creates the opportunity for learners to move from practice as a college diploma prepared RPN to an RN through earning a Bachelor of Science in Nursing (BScN) degree.
Topic: Nursing bridging education
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Aim: The aim of the study was to explore fi ve years survival in women with endometrial cancer. Material and methods : A retrospective review of 146 patients with endometrial cancer treated at Baskent University Hospital Gyne-oncologic Clinic in Ankara, Turkey between 2010 and 2015 was performed. Demographic and clinic-pathological data were compared with survival.
Topics: Endometarial cancer, survival
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Objective : The study was conducted as a descriptive and cross-sectional to determine nurses’ views on their profession in Turkey, their commitment to the profession and participation in professional activities and influencing factors. Methods: The study sample comprised 2253 nurses working in hospital in Turkey. The data were collected using a questionnaire developed by the researchers. For the assessment of the data, percentages,the chi square and multiple logistic regression analysis were...
Topic: Nurses’ Views on Their Profession in Turkey and Influencing Factors
Good nursing care is a key factor in reducing the most common complications related to immobility like pressure ulcers (PU), deep vein thrombosis (DVT) in spinal cord injury (SCI) patients. Materials and methods : The study was conducted using a pre-experimental, time series design on 52 nurses and 73 patients with SCI (30 before and 43 after the intervention) enrolled by universal sampling technique in a trauma ICU of a tertiary care facility to evaluate the effectiveness of ICU Prophylaxis ...
Topic: A Pre-Experimental Study to Evaluate the Effect of ICU Prophylaxis Program
Introduction : Congenital Heart Diseases (CHD) do not preclude the possibility to become adult due to the different innovations in medical and surgical treatments. The transition from childhood to adulthood is a complex process in the life of CHD adolescents, considering the consequences of their diseases and  the need to be adherent with their follow-up indications. In this process, parents play an important role, being a landmark for their children, but the experiences of CHD adolescents’...
Topics: cancer, public people
Cancer is still the most difficult diagnosis that the physicians encountered and found themselves facing the issue of announcement and disclosure of a diagnosis for both families and patients. Aim: The aim of this study is to assess the attitudes of the public people toward the disclosure of cancer diagnosis to patients in Saudi Arabia.
Topics: cancer, public people
Introduction : The Erasmus Intensive Programme (IP) is a short term programme of study lasting from 10 continuous days to a maximum of six weeks of subject related work by bringing together students and staff from higher education institutions of at least three EU countries.
Topics: Elder care, Nursing education, Erasmus intensive programmes, Lifelong learning
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The population is aging. Gratton (2016) writes that we will soon be living to 100. The nursing profession has a major role today in promoting, supporting and maintaining healthy habits and resilience in this aging group of women and men [1].
Topic: Resilience in later life: A critical role for Nursing?
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Summary: Mary Frances Crowley nurse, midwife and nurse and midwifery tutor was founder member and first Dean of the Faculty of Nursing and Midwifery in the Royal College of Surgeons in Ireland. She started the Medical Missionaries Midwifery Training School at the International Hospital, Drogheda in 1942. She was a visionary who was instrumental in the development of education and professional development for nurses and midwives in Ireland. She lived and worked by her values and principles and...
Topic: Mary Frances Crowley
The study examined changes in HIV/AIDS-related knowledge, attitudes, and beliefs between cohorts of Cameroonian, Honduran, and American nursing students across iterations of a train-the-trainer program. Following a didactic course on HIV/AIDS, two subsets of American students led an educational workshop in Cameroon and Honduras. Fifty-three Cameroonian, 31 Honduran, and 33 American nursing students were evaluated prior to the course or workshop, at the program’s conclusion, and 60 days later....
Topics: Nursing students, Train the trainer
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Nov 23, 2018
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Aim: To inform about the prevention of child abuse and neglect. Method : This study was prepared as a compilation. The studies published between 2000 and 2017 were reviewed, researchers searched the keywords of “child abuse, child neglect, prevention, nurse” in Turkish and English on the international “PubMed”, “Embase”, “Ovid”, “ProQuest”, “Ebscohost” and national Turkish Medical Index.
Topics: child abuse, child neglect
Background : The multiple sequelae caused by traumatic brain injuries (TBIs) can considerably reduce the ability of seniors to resume their activities of daily living and their leisure activities, and to return to meaningful relationships so they can participate in the life of their community. Purpose of the study : This article aims to put forward the perceptions of older participants about the sequelae they themselves identify as consecutive, short or medium long term, with their TBI and...
Topic: Towards a better understanding of the impact
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Objectives: Our study aimed to investigate patient safety attitudes and perceptions amongst health care providers in Tunisian tertiary care hospitals. Methods : This cross-sectional study was conducted during April May and June 2015 in Sahloul  University hospital in Sousse: a 630-beds tertiary hospital in Eastern Tunisia. This survey included 344 cares providers. The French version of the Hospital Survey on Patient Safety Culture questionnaire was used to identify dimensions of patient safety...
Topic: Patient Safety Culture in a Tunisian
Objectives: This study investigated the correlations between the organizational politics perception,job satisfaction, job stress, and organizational commitment of the hospital employees in a medical centre.This will allow managers at various levels to understand better the organizational politic perception of the hospital nursing staff, which will enable them to reduce the negative impacts of hospital nursing staff’sorganizational politics perception and job stress, and improve the job...
Topics: Relational Model of Organizational Politics Perception, Job Satisfaction, Job Stress
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Nov 23, 2018
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In the modern era of widespread utilisation of imaging procedures for preoperative diagnosis and minimal invasive surgeries, intravenous contrast plays a major role in delineation of variety of information related to vascularity of normal as well as abnormal tissues. Vascular structures may themselves be focus of  attention for various vascular interventional procedures, again requiring intravenous contrast. Since the intravenous contrast agent used in the imaging procedures is primarily...
Topic: Contrast Induced Nephropathy - A Review
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Mucormycosis is one of the invasive fungal infections particularly in immunocompromised patients with impaired host defense. It is characterized by fungal rhino sinusitis with invasion of adjustment structures including brain, pulmonary, or gastrointestinal systems or can be presented as a disseminated disease. Predisposing factors are diabetic ketoacidosis, neutropenia, corticosteroid or deferoxamine use, iron overload, malnutrition and skin macerations. We present a known case of end-stage...
Topic: End-Stage Renal Disease Patient with Invasive
Background: Procalcitonin (PCT) has been proposed as a novel biomarker for prediction of Vesicoureteral Refl ux (VUR). Since VUR is the most important risk factor for occurrence of pyelonephritis and renal tissue infl ammation, serum PCT level may have a relationship with VUR. However, literature about the relationship between procalcitonin level and VUR is scanty. 
Topics: Urinary tract Infection, Procalcitonin lev- els, Vesicoureteral re fl ux, Voiding cystourethrogram
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Nov 23, 2018
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Cardiac diseases are associated independently with decrease in kidney function and progression of existing kidney diseases. Conversely, chronic kidney disease (CKD) represents an independent risk factor for cardiovascular events and outcomes. Renal dysfunction frequently accompanies cardiac failure and that cardiac dysfunction frequently accompanies renal failure. This interdependent relationship has come to be known as the “cardiorenal syndrome”. Direct and indirect effects of each organ...
Topic: Cardiorenal Syndrome
Sudden cardiac arrest (SCA) is defi ned as sudden, unexpected loss of heart function, breathing and consciousness, resulting from an electrical disturbance in the heart stopping its action and blood fl ow, and cardiovascular diseases are the major risk factors for SCA. It has been reported that more than 20%  of all deaths in patients with advanced chronic kidney disease is due to arrhythmias and SCA [1].
Topics: Cardiorenal Syndrome, Cardiac Diseases, Renal Dysfunction, Chronic Kidney Disease, Neuro- hormonal...
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Gemcitabine (2’,2’-difl uorodeoxycytidine) is a potent pyrimidine antimetabolite and was introduced in 1987. It is commonly used for various tumors including non-small cell lung cancer, pancreatic cancer, breast cancer, ovarian can cer and renal cell carcinoma at advanced stages. Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia and acute kidney injury. We report here a 45-year-old male patient with duodenal cancer, who developed...
Topics: Acute Kidney injury, Gemcitabine, Plasma- pheresis, TMA
Introduction: The benefi t of combination immunosuppression versus steroid monotherapy in pure membranous lupus nephritis (MLN) remains unclear. Steroid monotherapy could potentially reduce exposure to excessive immunosuppression in patients achieving remission with this strategy. The aim of this study was to defi ne patient characteristics and outcomes in MLN treated with steroid monotherapy. Method: A retrospective, observational study identifi ed all biopsy-proven pure MLN cases followed...
Topic: Steroid Monotherapy for the Treatment for Pure Membranous Lupus Nephritis
Phenazopyridine, an azo dye, is commonly used to relieve dysuria caused by bladder irritation or infection. We report the case of a 64-year-old lady who presented with unexplained sub-acute onset hemolytic anaemia followed by acute kidney injury (AKI) and jaundice. This created a diagnostic dilemma until concealed phenazopyridine abuse was discovered. Discontinuation of Phenazopyridine improved renal function and hemoglobin level to baseline without any other intervention. Prompt urinalysis...
Topic: Phenazopyridine abuse presenting with acute kidney injury
Induction therapy has established itself as an integral component of modern-day renal transplantation. Carefully selected induction therapy helps not only to avoid early rejection of grafts but also allows grafts  with delayed function to recover prior to introduction of potentially nephrotoxic immunosuppressants. While the place of induction therapy and reduction in early acute rejection is well established, its overall impact on long-term graft and patient survival is still unclear,...
Topics: Induction, Low risk transplant
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Encapsulating peritoneal sclerosis (EPS), is a rare but devastating complication of long-term peritoneal dialysis (PD) with a high mortality rate. The incidence is between 0.5 and 3.3%, decreasing with time. EPS is defi ned as a clinical syndrome with major signs of gastrointestinal obstruction, infl ammatory parameters, radiological and macroscopic changes. Duration of treatment and cessation of PD are the main risk for development of EPS: about 75% of EPS occurred in patients transferred on...
Topic: Encapsulating Peritoneal Sclerosis: Case report and Current Status
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About 30-40% of patients with chronic kidney disease (CKD) patients also have concomitant diabetes (1). Diabetes has been shown to have signifi cantly stronger association with CKD in patients with younger age (2). Diabetes management in CKD poses signifi cant challenge because of the increased risk of hypoglycaemia, renal excretion of most oral antidiabetics, variable appetite of patients with CKD and the effects of hemodialysis and peritoneal dialysis on glycemic control. Management of...
Topic: Management of type 2 Diabetes in patients
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Background: Unroofi ng is a controversial procedure to avoid catheter removal in the treatment of the chronic exit site and tunnel infection, but is now rarely recommended. Here we aimed to evaluate the effects of the unroofi ng procedure on peritoneal catheter survival. 
Topic: Peritoneal catheter survival: The impact of unroofing
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Nov 23, 2018
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Research in Tolerance and Chimerism by Transplant immunologists for over half a century is akin to the pursuit of the Holy Grail. Animal experiments for inducing tolerance may not have been successful initially but in that process, our knowledge of the fascinating immune system has been greatly enriched. Understanding of innate and adaptive immune systems has paved the way for development of potent immunosuppression. However, achieving clinical or operational tolerance long term in renal...
Topics: Tolerance, Tolerogenic
During the last decade, the link between Human Immunodefi ciency Virus (HIV) infection and cardiovascular disease has received much attention. Recent meta-anaylsis by Islam et al. [1], concluded that HIV infection increases the risk of cardiovascular diseases (CVD). They found the relative risk (RR)
Topic: Hepatitis C – Human Immunode fi ciency Virus Coinfection and the Risk of Cerebro-Cardiovascular...
Current efforts to fi nd a cure for HIV disease require that viral load assays be available to accurately detect and measure viral load in compartments other than peripheral blood. Over the years, HIV viral load assays have been adapted to measure viral presence in cerebral spinal fl uid (CSF), genital secretions and various other compartments. In this study we describe our efforts to quantitatively recover HIV-1 from pooled pediatric bone marrow plasma spiked with known concentrations of HIV-1...
Topic: Feasibility of HIV-1 RNA Extraction and Viral Load Testing of Bone Marrow Plasma Using the Abbott m...
We describe the care burden derived of a lung cancer screening program in HIV high risk patients. In a well selected group with the described criteria, one annual low-dose thoracic computed tomographic exploration can be applied to a 7.2% of the patients attended (95%CI 4.2-9.6), with at least one follow-up exploration in another 1.3% with the generation of at least two extra visits for explanation of the protocol and results.  If  smoking  habit  does  not  change  over  the  next ...
Topic: Care burden derived from the introduction of an early Lung Cancer Screening Program in high risk...
Background: One of the particularities of human immunodefi ciency virus (HIV) infection in the tropics is its frequent association with parasitic diseases so frequent in this area. Aim: The aim of this study was to update the epidemiological and clinical profi le of intestinal parasites among HIV-positive patients in the era of combination antiretroviral therapy (ART) and preventive treatment in Ouagadougou, Burkina Faso.
Topics: Epidemiology, Opportunistic intestinal parasites, HIV infection, Ouagadougou
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Healthcare Is the fastest growing sector (5.6% increase in 2016) of the United States economy,comprising 17.8% ($3,2 trillion) of the gross domestic product. There are more than 18,000,000 American healthcare professionals (HCP) [1,2]. HCP face many noninfectious occupational hazards. This includes hazardous chemicals, latex allergies, lasers, radiation, stress, violence, strains, sprains and heat/fi re. Also, HCP are commonly exposed to infectious agents, including the hepatitis B virus (HBV),...
Topic: Occupational Acquisition of HIV Infection by Healthcare Workers in the United States
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Though the HIV/AIDS prevalence rate in The Gambia is one of the lowest in the sub-region, the disease and its associated effects has always been a concern both to the government, non-governmental organizations, professionals, families, communities, development partners, etc. Over the decade a number of studies have been conducted in the areas of its mode of transmission, prevention, impacts, etc. However, there is none on the disease and the mobile population. The young female petty traders in...
Topics: Petty traders, Long-distance drivers, HIV/ AIDS, Risk, Long-distance
With over a million people diagnosed with HIV by the beginning of 2016, Russia has one of the world’s most rapidly developing HIV epidemics. Evidence suggests young women in Russia are at high risk for HIV  and comprise a substantial portion of newly infected people. Our study is one of the first to explore via qualitative interviews among young Russian women in HIV care in St. Petersburg (N=30) the role of alcohol use in their HIV treatment adherence and sexual behaviors. Our study reveals...
Topics: HIV, Russia, Antiretroviral treatment, Alcohol, Sexual risk
Background : Regular physical activity increases physical fitness and lowers ventilation during mild and moderate exercise thereby reducing the likelihood of provoking exercise-induced asthma. Regular exercise may also reduce the perception of breathlessness through a number of mechanisms including strengthening respiratory muscles. Subjectively, many asthmatics report that they are symptomatically better when fit, but results from trials have varied and have been difficult to compare because...
Topic: Pulmonary Rehabilitation Using Regular Physical Exercise for the Management of Patients with Asthma
Tumor surgery in the orofacial region frequently requires resection of major parts of the jawbone and the adjacent facial and pharyngeal soft tissue resulting in large-scale hard and soft tissue defects. Consequences of such defects may include masticatory dysfunction, speech disturbances and swallowing problems as well as significant aesthetic impairment for the patients concerned. Thus, comprehensive therapy with reconstruction of the missing tissue and subsequent prosthetic rehabilitation is...
Topic: Prosthetic Functional Rehabilitation
Spatial temporal gait variability has developed into a measure of interest in clinical gait analysis. It is capable of providing unique insight into rhythmic stability of human gait and may be a sensitive biomarker of falls risk. Several lines of evidence support the use of spatial temporal gait variability as a clinical measures. The purpose of this review is to provide a brief, practical review, of spatial temporal gait variability. This review discusses how gait variability data is obtained,...
Topics: Gait variability, Gait, Spatial temporal, Falls, Review, Clinical practice, Therapy, Rehabilitation
Background : Exercise intolerance (EI) is a cardinal feature in subjects with heart failure with preserved ejection fraction (HFpEF). Factors related to EI in such patients are not completely understood. The association between right ventricular (RV) dysfunction and pulmonary hypertension (PH) with EI has been poorly investigated so far. We hypothesized that RV function measured by Tricuspid Annular Plane Systolic Excursion (TAPSE)/Pulmonary Arterial Systolic Pressure (PASP) ratio would predict...
Topic: Right Ventricular Dysfunction is related with Poor Exercise
Background and objectives: Motor-level electrical stimulation (MES) has been shown to improve glucose tolerance and glucose uptake in both animals and humans.  Recently, MES has been shown to improve the blood glucose control in people with Type 2 Diabetes (T2D).  There are several types of MES applied in physical therapy clinics.  However, it is unknown what types of MES optimally decrease postprandial glucose level.  The purpose of this study was to compare the effects of three different...
Topics: Electrical stimulation, Type 2 diabetes, Glucose Level, Muscle